Download Antibody Fc: Chapter 11. Activating and Inhibitory FcγRs in by Falk Nimmerjahn PDF

By Falk Nimmerjahn

Autoimmune problems are characterised through the destruction of self-tissues by way of the immune process. a number of checkpoints are in position to avoid autoreactivity below basic conditions. Co-expression of activating and inhibitory Fc receptors (FcRs) represents this type of checkpoint through setting up a threshold for immune phone activation. in lots of human autoimmune illnesses, even if, balanced FcR expression is disturbed. research of murine version platforms offers robust facts that aberrant FcR expression can lead to out of control immune responses and the initiation of autoimmune disorder. This evaluation summarizes those information and explains how this knowledge could be used to raised comprehend human autoimmune illnesses and to enhance novel healing strategies.

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